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| Nitric Oxide | NO2 Vsodilators
| 1. What is Nitric Oxide and where does it come from?
Nitric Oxide is a free form gas that is produced in the body and is used by the
body to communicate with other cells in the body. To produce this gas, enzymes
in the body break down the amino acid Arginine.
Nitric Oxide is a molecule consisting of one atom of nitrogen and one atom of
oxygen. The production of Nitric Oxide occurs when the amino acid L-arginine is
converted into L-citruline through an enzyme group known as Nitric Oxide
Synthase (NOS). The chemical process of conversion is shown in figure 1.
2. What does Nitric Oxide do and what scientific studies give evidence to
support this?
Despite the claims of some in the supplement industry, there exists ample
scientific literature to substantiate the efficacy of Nitric Oxide products. The
following was written in May 1996 in a document prepared for the Royal Society
and Association of British Science Writers:
"Summary research papers continue to flood the scientific journals and insights
into the biological activity and potential clinical uses of nitric oxide (NO): a
gas controlling a seemingly limitless range of functions in the body. Each
revelation adds to nitric oxide's already lengthy resume in controlling the
circulation of the blood, regulating activities of the brain, lungs, liver,
kidneys, stomach and other organs.
The molecule governs blood pressure through a recently recognized process that
contradicts textbook wisdom. It causes penile erection by dilating blood vessels
and controls the action of almost every orifice from swallowing to defecation.
The immune system uses nitric oxide in fighting viral, bacterial and parasitic
infections, and tumors. Nitric oxide transmits messages between nerve cells and
is associated with the process of learning, memory, sleeping, feeling pain, and,
probably depression. It is a mediator in inflammation and rheumatism."
Since the above was written in 1996, Nitric Oxide containing products have
continued to be touted by those in the medical profession, as well as by
athletes looking to add muscle to their frames.
The above quotation states that Nitric Oxide controls the circulation of blood,
transmits messages between nerve cells, and is a mediator of inflammation and is
associated with the process of feeling pain. The popular erectile dysfunction
drug sildenafil citrate (Viagra) contains nitric oxide and is responsible for
increasing blood flow to the penis.
The fact that nitric oxide increases blood flow should make it of interest to
bodybuilders, as increased blood flow will serve to deliver more nutrients to
muscles, thus helping muscles become larger when subject to stress. The fact
that Nitric Oxide acts to reduce inflammation should also make it of interest to
bodybuilders as it has the potential to reduce the pain associated with
subjecting muscles to extreme stress.
Nitric oxide also affects the endocrine system. It affects the release of
gonadotroptin releasing hormone, as well as the release of adrenaline from the
adrenal medulla.
3. Who needs Nitric Oxide and what are some symptoms of deficiency?
Everyone REQUIRES nitric oxide to carry out key physiological processes within
the body. From a bodybuilder's perspective, nitric oxide supplementation may
prove useful in increasing growth due to increases in blood flow to certain
areas of the body. Further, men suffering from erectile dysfunction may also
find supplementing with nitric oxide helpful.
Signs of deficiency include the inability to achieve and sustain erections,
physical weakness and extreme fatigue. Most "nitric oxide" supplements contain
the amino acid Arginine-alpha-keto-glutarate.
4. How much Nitric Oxide should be taken? Are there any side effects?
With any amino acid containing product, overdose is a possibility. Dosing with
too much arginine can lead to diarrhea, weakness and nausea. Clear dosing
guidelines have not been established, so it is best to do what is known as
"tolerance mapping". Take a small dosage for one week, note the benefits and the
side effects, and increase the dosage until the benefits are maximized and the
side effects minimized. Over time the two will converge and you will hit the
optimal dose. This process is similar to "receptor mapping" for bodybuilders who
use insulin.
Many protein powders are fortified with amino acids, including arginine. With
this in mind, pay particular attention to how much arginine you are ingesting
from all supplements taken.
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Post Workout Nutrition
Workout recovery is a very important issue for the serious athlete. There is some confusion about what is the best nutritional strategy to optimize recovery and growth after exercise. As is the case with many issues in nutrition, there is no single best answer. The best approach depends on what kind of athlete you are and what your goals are. There are some common questions we at Parrillo Performance receive relate to the role of carbohydrates in the post-exercise environment. We are often asked: should my post-exercise meal include protein or carbohydrate? Or both? And just how much is enough? Is timing important? When is the best time to take Creatine? Optimal nutrition for a bodybuilder is different from that for an endurance athlete. Optimal nutrition varies individual to individual and circumstance to circumstance. Are you trying to optimize your physique, strength or endurance performance? Different goals require different methods. So when you hear conflicting opinions about the best diet or supplement, remember there is no single correct answer. We have to tailor the answer for each individual. I will share with you the principles that will allow you to customize your very own diet and nutritional supplementation program. For some background let’s rehash some biochemistry. During exercise your muscles use mainly carbohydrate and fat as fuel. Sometimes, during prolonged activity (like distance running) you will burn protein stores. Protein oxidation in exercise occurs after glycogen stores are significantly depleted. For high intensity activity such as weight lifting (as opposed to long duration exercise like aerobics), carbohydrate is the primary fuel. For endurance activities like jogging or cycling, a mixture of carbohydrate and fat is used. As the exercise proceeds, muscle and liver glycogen stores become progressively depleted. It would make sense to replace the depleted fuel in order to keep our work output high. Furthermore, if our goal is to gain muscle then we need to supply the raw materials to support growth. We can do both simultaneously. Insulin levels decrease markedly during exercise and this allows the release of fat from adipose cells. The goal of our post-exercise recovery meal is to replenish energy stores depleted during the just-completed session. Insulin plays a central role in nutrient storage, acting to transport carbohydrates and some amino acids from the bloodstream to the individual cells. Insulin also stimulates the storage of carbohydrate as glycogen. Significantly, carbohydrate is a potent stimulus for insulin release while protein’s effect on insulin is far more subdued. Athletes have long practiced eating a high carbohydrate meal after exercise and this makes a lot of sense. A high carb post-workout feeding serves to increase insulin levels and replenish glycogen stores. And this is a good thing: by replenishing drained nutrients and dousing exhausted muscles with nourishing carbohydrates, we promote muscle healing and growth in the post-workout state. Should this post-workout feeding also contain protein? And exactly how much carbohydrate and protein is optimal? What type? Are simple sugars or refined carbohydrates better in the post-workout environment? I never recommend eating simple sugars or referred carbohydrates – post workout or any other time - for several reasons: simple sugars and refined carbohydrates are far more likely to be converted to fat than complex carbohydrates. It’s all a matter of chemistry. If the sugar enters your bloodstream faster than it can be stored as glycogen, the excess will be converted to fat by the liver. No doubt about it! Some endurance athletes replenish glycogen with simple sugars or refined carbohydrate but this strategy is bad news for bodybuilders. A serious bodybuilder wants to minimize fat accumulation and therefore simple sugars and refined carbohydrates have no place in the diet of a top bodybuilder - even after a workout. Every meal should supply a mixture of protein and carbohydrate, including the post-exercise meal. In addition to replenishing glycogen stores, the post-exercise meal serves to re-supply amino acids used to repair muscle tissue. Several medical studies have examined how the composition of the recovery meal affects hormone levels critical for muscle growth (1-3). A post-workout feeding of carbohydrate and protein is demonstrably more effective at increasing insulin and growth hormone levels than ingesting carbohydrate alone. This translates into a far more potent anabolic stimulus, resulting in greater muscle accrual. Also, this combination is more effective at replenishing glycogen stores than carbohydrate alone (3). Since the goal is to heal and build muscle, the optimal recovery meal should contain a mixture of protein and carbohydrate. How much carb and protein per post-work out feeding is optimal? The answer is not precise - and may never be. It varies depending on your goals and bodyweight. It you want to gain size the post-workout meal should contain more calories than if you are desirous of losing bodyfat. In previous articles I have explained at length how to determine the proper number of calories to consume to effect muscle gains or fat loss. After you determine your caloric breakeven point, divide your daily allotment of calories into five or six meals, each containing approximately the same number of calories. One of these meals should be your post-workout meal. Theoretically, your post-workout meal should actually be your biggest meal of the day. Why? The body is more efficient at oxidizing food in the post-workout state. If you are seeking to add quality muscle size, I suggest calculating how many calories each meal should contain on average and make the recovery meal one-and-a-half times the average meal calorie total. Conversely, if you are trying to lose weight, then the post-workout meal should contain the same caloric content as the other meals. Through scientific research and years of working with the world’s top bodybuilders, I have found that a mixture of about 50% protein and 50% carbohydrates is ideal for a post-workout feeding. This is the rationale and basis for our 50-50 Plus Powder™, which is the ideal post-workout recovery drink. Many people rely on supplements after working out because few are hungry for solid food immediately after exercise. Our nutrition Bars are another easy way to get quality calories in after a workout - and convenient also. They are available in several different protein-carbohydrate ratios to suit your individual needs. Timing is important: the sooner you eat after a high intensity training session the better off you will be. There exists a “window of nutritional opportunity” that opens immediately after exercise during which glycogen re-synthesis rates are maximal. This window stays open for roughly two hours after the cessation of exercise (6). Considering that it takes some time for the nutrients to be digested and absorbed, I would suggest you eat your recovery meal as soon as you can after exercise, to take advantage of the open window before it snaps shut. This is another reason why supplements are ideal as post-exercise meals. They are easy to prepare and quickly absorbed. A shaker bottle with four to six scoops of 50-50 Plus Powder™, placed in your gym bag makes an ideal post workout recovery drink. In edition to the 50/50 Plus Powder™ it is imperative you get a meal within 2 hours of completion of your workout. Next month we can talk in more detail about carbohydrate metabolism during exercise and go into carbohydrate and fluid repletion during exercise. References Chandler RM, Byrne HK, Patterson JG, and Ivy JL. Dietary supplements affect the anabolic hormones after weight training exercise. J. Appl. Physiol. 76(2): 839-845, 1994.
Rabinowitz D, Merimee TJ, Maffezzoli R, and Burgess JA. Patterns of hormonal release after glucose, protein, and glucose plus protein. Lancet 2: 454-457, 1966.
Zawadzki KM, Yaspelkis BB, and Ivy JL. Carbohydrate-protein complex increases the rate of muscle glycogen storage after exercise. J. Appl. Physiol. 72: 1854-1859, 1992.
Nicholas CW, Green PA, Hawkins RD, and Williams C. Carbohydrate intake and recovery of intermittent running capacity. Int. J. Sports Nutr. 7: 251-260, 1997.
Pizza FX, Flynn MG, Duscha BD, Holden J, and Kubitz ER. A carbohydrate loading regimen improves high intensity, short duration exercise performance. Int. J. Sports Nutr. 5: 110-116, 1995.
Liebman M and Wilkinson JG. Carbohydrate metabolism and exercise. Chapter 2 in Nutrition in Sport and Exercise, Wolinsky and Hickson, editors. CRC Press, Boca Raton, 1994.
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